Which transporter is primarily responsible for renal glucose reabsorption in the proximal tubule?

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Multiple Choice

Which transporter is primarily responsible for renal glucose reabsorption in the proximal tubule?

Explanation:
Glucose reabsorption in the proximal tubule happens by sodium-dependent transporters on the luminal surface and glucose exiters on the basolateral side. The main player on the luminal side in the early proximal tubule is SGLT2, which reclaims the majority of filtered glucose by coupling glucose uptake to sodium entry. Inside the cell, glucose exits via GLUT2 on the basolateral membrane into the blood. GLUT4 isn’t involved in kidney glucose transport. SGLT1 does contribute a smaller portion in the later proximal tubule, but the primary transporter responsible for the bulk of proximal tubule glucose reabsorption is SGLT2.

Glucose reabsorption in the proximal tubule happens by sodium-dependent transporters on the luminal surface and glucose exiters on the basolateral side. The main player on the luminal side in the early proximal tubule is SGLT2, which reclaims the majority of filtered glucose by coupling glucose uptake to sodium entry. Inside the cell, glucose exits via GLUT2 on the basolateral membrane into the blood. GLUT4 isn’t involved in kidney glucose transport. SGLT1 does contribute a smaller portion in the later proximal tubule, but the primary transporter responsible for the bulk of proximal tubule glucose reabsorption is SGLT2.

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